Scientific Publications

nACh Selected Publications:

Zhu, Heeschen, Sievers, Karliner, Parmley, Glantz, and Cooke: Second hand smoke stimulates tumor angiogenesis and growth; Cancer Cell: Vol. 4, Sept. 2003

Javier Cuevas and Darwin K. Berg: Mammalian Nicotinic Receptors with α7 Subunits That Slowly Desensitize and Rapidly Recover from α-Bungarotoxin Blockade; The Journal of Neuroscience: December 15, 1998, 18(24):10335–10344

Heeschen, Jang, Weis, Pathak, Kaji, Hu, Tsao, Johnson & Cooke: Nicotine stimulates angiogenesis and promotes tumor growth and atherosclerosis; Nature Medicine: Vol. No. 7, July 2001

Suñer, Espinosa-Heidmann, Marin-Castano, Hernandez, Pereira-Simon, and Cousins: Nicotine Increases Size and Severity of Experimental Choroidal Neovascularization; Investigative Ophthalmology & Visual Science: Vol. 45 No. 1, January 2004

Heeschen, Weis, Aicher, Dimmeler, and Cooke: A novel angiogenic pathway mediated by non-neuronal nicotinic acetylcholine receptors; The Journal of Clinical Investigation: Vol. 110 No. 4, August 2002

Kiuchi K, Matsuoka M, Wu JC, Lima E Silva R, Kengatharan M, Verghese M, Ueno S, Yokoi K, Khu NH, Cooke JP, Campochiaro PA.: Mecamylamine suppresses Basal and nicotine-stimulated choroidal neovascularization.; Invest Ophthalmol Vis Sci. 2008 Apr;49(4):1705-11.

BACE Selected Publications:

Luo, Bolon, Kahn, Bennett, Babu-Khan, Denis, Fan, Kha, Zhang, Gong, Martin, Louis, Yan, Richards, Citron and Vassar: Mice deficient in BACE1, the Alzheimer's   β-secretase, have normal phenotype and abolished β-amyloid generation; Nature Neuroscience: Vol. 4 No. 3, March 2001

Martin Citron: β-Secretase inhibition for the treatment of Alzheimer’s disease – promise and challenge; TRENDS in Pharmacological Sciences: Vol.25 No.2, February 2004

Hock, Konietzko, Streffer, Tracy, Signorell, Muller-Tillmanns, Lemke, Henke, Moritz, Garcia, Wollmer, Umbricht, de Quervain, Hofmann, Maddalena, Papassotiropoulos, Nitsch: Antibodies against β-Amyloid Slow Cognitive Decline in Alzheimer’s Disease; Neuron: Vol. 38, 547–554, May 22, 2003

Hong, Koelsch, Lin, Wu, Terzyan, Ghosh, Zhang, Tang: Structure of the Protease Domain of Memapsin 2 (β-Secretase) Complexed with Inhibitor; Science: Vol. 290, October 6, 2000

Lin, Koelsch, Wu, Downs, Dashti, and Tang: Human aspartic protease memapsin 2 cleaves the β-secretase site of β-amyloid precursor protein; PNAS: Vol. 97 No. 4, February 15, 2000

Alpha 7 nAChR Selected Publications:

Olincy, Harris, Johnson, Pender, Susan Kongs, Diana Allensworth, Jamey Ellis, Zerbe, Leonard, Stevens, Stevens, Martin, Adler, Soti, Kem, Freedman: Proof-of-Concept Trial of an α Nicotinic Agonist in Schizophrenia: Arch Gen Psychiatry: Vol. 63, June 2006

Young, Crawford, Kelly, Kerr, Marston, Spratt, Finlayson, Sharkey: Impaired attention is central to the cognitive deficits observed in alpha 7 deficient mice; European Neuropsychopharmacology: 2006

Michael R. D’Andrea and Robert G. Nagele: Targeting the Alpha 7 Nicotinic Acetylcholine Receptor to Reduce Amyloid Accumulation in Alzheimer’s Disease Pyramidal Neurons; Current Pharmaceutical Design: 2005, 11

Kitagawa, Takenouchi, Azuma, Wesnes, Kramer, Clody, and Burnett: Safety, Pharmacokinetics, and Effects on Cognitive Function of Multiple Doses of GTS-21 in Healthy, Male Volunteers; Neuropsychopharmacology: 2003, 28, 542-551

Snyder, Nong, Almeida, Paul, Moran, Young Choi, Nairn, Salter, Lombroso, Gouras & Greengard: Regulation of NMDA receptor trafficking by amyloid-β; Nature Neuroscience: Vol. 8 No. 8, August, 2005